Publications prior to HKUST

60. Ligand-Controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights

Li Li, Feifei Song, Xiumei Zhong, Yun-Dong Wu, Xinhao Zhang,* Jiean Chen,* and Yong Huang.* Adv. Synth. Catal. 2019, 361, 1–8

59. Alcohol-Directed ortho-C–H Alkenylation

Li Li, Qinglan Liu, Jiean Chen *, Yong Huang *. Synlett 2019, 30, A-E. DOI: 10.1055/s-0037-1611538

58. Enantio- and Diastereoselective Hydrofluorination of Enals via N-Heterocyclic Carbene Catalysis

Leming Wang, Xinhang Jiang, Jiean Chen,* Yong Huang*. Angew. Chem. Int. Ed. 2019. DOI:10.1002/anie.201902989

57. N‐Heterocyclic Carbenes as Brønsted Base Catalysts

Jiean Chen, Yong Huang. Book Author(s): Akkattu T. Biju. DOI :10.1002/9783527809042.ch9

56. Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation

Wang Zhen, Li En, He Zhiqi, Chen Jiean, Huang Yong. Acta Phys. -Chim. Sin. 2019, 35, 0001–0009. DOI: 10.3866/PKU.WHXB201811038.

55.Switching Reaction Pathways by Cooperative Catalysis of N-Heterocyclic Carbene and Lewis Acids

Wang Leming, Wang Qian, Chen Jiean*, Huang Yong*. Acta Chim. Sinica 2018, 76, 850—856.

54. Structure-Based Drug Design and Identification of H2O‑Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo
Peichen Pan, Jiean Chen,§ Xijian Li,§ Miyang Li,§ Huidong Yu, Jean J. Zhao,⊥,# Jing Ni,⊥,#Xuwen Wang, Huiyong Sun, Sheng Tian, Feng Zhu, Feng Liu, Yong Huang,*,§ and Tingjun Hou*,†,‡  J. Med. Chem. 2018, XXX, XXX−XXX. DOI: 10.1021/acs.jmedchem.8b00498

53. Aerobic Oxidation/Annulation Cascades via Synergistic Catalysis of RuCl3 and N‐Heterocyclic Carbenes

Qian Wang,  Jiean Chen*,  Yong Huang*.  Chem. Eur. J. 2018, 24, 12806 – 12810. DOI: 10.1002/chem.201803254 

52. Enantioselective hydroamidation of enals by trapping of a transient acyl species

Pengfei Yuan, Jiean Chen*, Jing Zhao*, Yong Huang*. Angew. Chem. Int. Ed. 2018. 57, 8503 –8507. DOI: 10.1002/anie.201803556

51. A Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metallate Shift

Zhiqi He, Feifei Song, Huan Sun, and Yong Huang*. J. Am. Chem. Soc. 2018, 140, 2693-2699. DOI: 10.1021/jacs.8b00380

50. Streamlined asymmetric α-difunctionalization of ynones

Siyu Peng1, Zhaofeng Wang1, Linxing Zhang, Xinhao Zhang* & Yong Huang*. Nat. Commun. 2018, 9, 375. DOI: 10.1038/s41467-017-02801-9

49. Enantioselective Cooperative Proton-Transfer Catalysis using Chiral Ammonium Phosphates

Linrui Zhang, Pengfei Yuan, Jiean Chen* and Yong Huang*. Chem. Commun., 2018, 54, 1473. DOI: 10.1039/C7CC09549J

48. Direct Synthesis of Polysubstituted Aldehydes via Visible-Light-Catalysis

Fengjin Wu1, Leifeng Wang1, Jiean Chen*, David A. Nicewicz*, Yong Huang*. Angew. Chem. Int. Ed. 2018, 57, 2174-2178. DOI: 10.1002/anie.201712384

47. Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- and β-C–H bonds through an Allyl–Iridium Intermediate

Zhen Wang1, Zhiqi He1, Linrui Zhang and Yong Huang*, J. Am. Chem. Soc., 2018, 140, 735−740. DOI: 10.1021/jacs.7b11351

46. Amine-Triggered 6p-Electrocyclization–Aromatization Cascade of Ynedienamines

Xijian Li, Huidong Yu, and Yong Huang*, Adv. Synth. Catal. 2017, 359, 1379 – 1387

45. Combating Drug-Resistant Mutants of Anaplastic Lymphoma Kinase with Potent and Selective Type‑I 1/2 Inhibitors by Stabilizing Unique DFG-Shifted Loop Conformation

Peichen Pan, Huidong Yu, Qinglan Liu, et al. Yong Huang*, and Tingjun Hou*, ACS Cent. Sci. 2017, DOI: 10.1021/acscentsci.7b00419


44. Construction of Pyridazine Analogues via Rhodium-mediated C-H Activation

Chao Yang, Feifei Song, Jiean Chen*, and Yong Huang*, Adv. Synth. Catal. 2017, 359, 3496-3502.

43. Enantioselective β‑Protonation of Enals via a Shuttling Strategy

Jiean Chen1, Pengfei Yuan1, Leming Wang, and Yong Huang*, J. Am. Chem. Soc. 2017, 139, 7045−7051.


42. Visible Light Mediated [4+2] Cycloaddition of Styrenes Synthesis of Tetralin Derivatives

Leifeng Wang, Fengjin Wu, Jiean Chen, David A. Nicewicz,* and Yong Huang*,  Angew. Chem. Int. Ed. 2017, 56, 6896-6900.


41.Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters

Fei Wang, Jiean Chen* and Yong Huang*, Synlett 2017,28, 1300-1304. (Invited Synlett Cluster



40. A Migratory Ether Formation Route to Medium-Sized Sugar Mimetics

Hao Jiang, Li-Ping Xu, Yan Fang, Zhen-Xing Zhang, Zhen Yang,* and Yong Huang*, Angew. Chem. Int. Ed., 2016, 55, 14340 –14344.


39. Diverting C−H Annulation Pathways Nickel-Catalyzed Dehydrogenative Homologation of Aromatic Amides

Zhiqi He and Yong Huang*,  ACS Catal. 2016, 6, 7814−7823.


38. Advances in the development of catalytic tethering directing groups for C–H functionalization reactions

Huan Sun, Nicolas Guimond* and Yong Huang*, Org. Biomol. Chem., 2016,14, 8389–8397.(Invited Perspective


37. Ligand-Assisted Palladium(II)/(IV) Oxidation for sp3 C-H Fluorination

Huan Sun, Yi Zhang, Ping Chen, Yun-Dong Wu*, Xinhao Zhang* and Yong Huang*,  Adv. Synth. Catal., 2016, 358, 1946.(Very Important Paper, Front Cover


36. New frontiers of N-heterocyclic carbene catalysis

Jiean Chen and Yong Huang*, Sci. China Chem., 201659, 251(Invited Perspective)

45 abstract


35. Asymmetric Sulfa-Michael Addition of α,β-Unsaturated Esters/Amides Using a Chiral N-Heterocyclic Carbene as a Noncovalent Organocatalyst

Pengfei Yuan, Sixuan Meng, Jiean Chen* and Yong Huang*, Synlett, 2016, 27, 1068.(Invited Synlett Cluster


34. Recent Progress in the Development of Multitasking Directing Groups for Carbon-Hydrogen Activation Reactions

Huan Sun and Yong Huang*, Synlett. 2015, 26, 2751. (Invited Account)


33. Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins

Leming Wang, Jiean Chen and Yong Huang*, Angew. Chem. Int. Ed. 2015, 54, 15414.


32. Asymmetric intramolecular α-cyclopropanation of aldehydes using a donor/acceptor carbene mimetic

Chaosheng Luo, Zhen Wang and Yong Huang*, Nature Commun. 2015, 6, 10041.


31. Highly enantioselective sulfa-Michael addition reactions using N-heterocyclic carbene as a noncovalent organocatalyst

Jiean Chen, Sixuan Meng, Leming Wang, Hongmei Tang and Yong Huang*, Chem. Sci. 2015, 6, 4184.


30. A Copper-Catalyzed Aerobic Domino Process for The Synthesis of Isoindolin-1-ylidene Derivatives

Hu Chen, Qian Wang and Yong Huang*, Tetrahedron 2015, 71, 3632. (Invited Contribution for a Special Issue)


29. Synthesis of Tetrasubstituted 1-silyloxy-3-aminobutadienes and Chemistry Beyond Diels–Alder Reactions

Xijian Li, Siyu Peng, Li Li and Yong Huang*, Nature Commun. 20156, 6913.


28. Direct Fluorination of Styrenes

Qian Shao, and Yong Huang*, Chem. Commun. 2015, 51, 6584-6586.



27. Synthesis of Indolo[2,1-a]isoquinolines via a Triazene-Directed C–H Annulation Cascade

Huan Sun, Chengming Wang, Yun-Fang Yang, Ping Chen, Yun-Dong Wu*, Xinhao Zhang* and Yong Huang*, J. Org. Chem. 2014, 79, 11863-11872.



26. Ruthenium-Catalyzed Redox-Neutral C–H Activation via N–N Cleavage: Synthesis of N-Substituted Indoles

Zhenxing Zhang, Hao Jiang and Yong Huang*, Org. Lett. 201416, 5976–5979.


25. Directed Arenealkyne Annulation Reactions via Aerobic Copper Catalysis

Yi Zhang, Qian Wang, Huidong Yu* and Yong Huang*, Org. Biomol. Chem. 201412, 8844-8850.


24. Highly ortho-Selective Trifluoromethylthiolation Reactions using a Ligand Exchange Strategy

Weiyu Yin, Zhaofeng Wang and Yong Huang*, Adv. Synth. Catal. 2014, 356, 2998 – 3006.


23. A General Synthesis of Ynones from Aldehydes via Oxidative C–C bond Cleavage under Aerobic Conditions

Zhaofeng Wang, Li Li and Yong Huang*, J. Am. Chem. Soc. 2014136, 12233–12236.


22. A multitasking functional group leads to structural diversity using designer C–H activation reaction cascades

 Ying Chen, Dongqi Wang, Pingping Duan, Rong Ben, Lu Dai, Xiaoru Shao, Mei Hong, Jing Zhao* and Yong Huang*, Nature Commun. 2014, 5, 4610.


21. Asymmetric catalysis with N-heterocyclic carbenes as non covalent chiral templates

Jiean Chen and Yong Huang*,  Nature Commun. 2014, 5, 3437.

NHC catalysis thumbnail

20. Selective synthesis of indazoles and indoles via triazene–alkyne cyclization switched by different metals

Yan Fang, Chengming Wang, Shengqin Su, Haizhu Yu* and Yong Huang*, Org. Biomol. Chem. 2014,12, 1061-1071.

FY triazene thumbnail


c3ob42088d 1061..1071 ++

19. Palladium catalyzed acetoxylation of benzylic C–H bonds using a bidentate picolinamide directing group

Tao Cheng, Weiyu Yin, Yi Zhang, Yingnan Zhang and Yong Huang*, Org. Biomol. Chem. 2014,12, 1405-1411.


CT benzylic oxidation thumbnail


 18.Direct α-Vinylidenation of Aldehydes and Subsequent Cascade Gold and Amine Catalysts Work Synergistically

 Zhaofeng Wang, Xijian Li, Yong Huang*, Angew. Chem. Int. Ed. 201342, 14219-14223.

TOCWZF-allenylation cover

17.Synthesis of α,β-unsaturated carbonyl compounds via a visible light promoted organocatalytic aerobic oxidation

Junlin Zhang, Leming Wang, Qi Liu, Zhen Yang*, and Yong Huang*, Chem. Commun. 2013, 49, 11662-11664.



16. Enantioselective synthesis of 1,2,4-triazolines catalyzed by a cinchona alkaloid derived organocatalyst

Qian Shao, Jiean Chen, Meihua Tu, David W. Piotrowski and Yong Huang*, Chem. Commun. 201349, 11098-11100.


15. Traceless Directing Strategy Efficient Synthesis of N-Alkyl Indoles via Redox-Neutral C–H Activation

 Chengming Wang and Yong Huang*, Org. Lett. 2013, 15, 5294-5297.


14. A Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines Quaternary Stereogenic Center Inversion and Functionalization

Chaosheng Luo and Yong Huang*, J. Am. Chem. Soc. 2013135, 8193–8196.

Highlighted by SYNFACTS, 2013, 9(8), 0898; DOI-10.1055s-0033-1339442.


13. General and Efficient Synthesis of Indoles through Triazene Directed C–H Annulation

Chengming Wang, Huan Sun, Yan Fang, and Yong Huang*, Angew. Chem. Int. Ed. 2013, 52, 5795-5798. (cover)

Highlighted by Chinese-Journal-of-Organic-Chemistry-2013-337-1593.


12. A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade

Tao Cheng, Sixuan Meng, and Yong Huang*Org. Lett. 201315 , 1958–1961.


11. Highly Practical Synthesis of Nitriles and Heterocycles from Alcohols under Mild Conditions by Aerobic Double Dehydrogenative Catalysis

Weiyu Yin, Chengming Wang and Yong Huang*Org. Lett. 2013, 15, 1850–1853.

Highlighted-by-SYNFACTS-2013-97-0722.-DOI_-10.1055_s-0033-1339227.Highlighted by organic chemistry portal


10. Highly trans Stereoselective Synthesis of Bicyclic Isoxazolidines via Copper Catalyzed Triple Cascade Catalysis

Hu Chen, Zhaofeng Wang, Yingnan Zhang and Yong Huang*, J. Org. Chem. 201378, 3503-3509.

Highlighted by SYNFACTS, 2013, 9(6), 0602. DOI: 10.1055/s-0033-1338792.


9. Computational study on mechanism of-RhIII-catalyzed oxidative Heck coupling of phenol carbamates with alkenes

Qi Zhang, Hai-Zhu Yu, Yi-Tong Li, Lei Liu, Yong Huang* and Yao Fu*, Dalton Trans. 201342, 4175-4184.


8. Expanding Structural Diversity Removable and Manipulable Directing Groups for C-H Activation

Chengming Wang, Yong Huang*, Synlett. 201324,145.(invited)


7. An Air-State Fe3S4 Complex with Properties Similar to Those of the HOXair State of the Diiron Hydrogenases

Yong Huang, Weiming Gao, Torbjõrn Åkermark, Mingrun Li, BjÖrn Åkermark*, Eur. J. Inorg. Chem. 201227, 4259-4263.


6.RhodiumIII Catalyzed C-H Activation of Arenes Using a Versatile and Removable Triazene Directing Group

Chengming Wang, Hu Chen, Zhaofeng Wang, Jiean Chen and Yong Huang*, Angew. Chem. Int. Ed. 201251, 7242-7245. (cover)

Highlighted by organic chemistry portal


5.One pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

Guiyong Wu, Weiyu Yin, Hong C. Shen,* and Yong Huang*, Green. Chem. 201214, 580-585. (cover)


4.General palladium catalyzed aerobic dehydrogenation to generate double bonds

Weiming Gao, Zhiqi He, Yong Qian, Jing Zhao* and Yong Huang*, Chem. Sci. 20123, 883-886.

Chem Sci Graphic Abstract

3. A Thiourea-Oxazoline Library with Axial Chirality Ligand Synthesis and Studies of the Palladium-Catalyzed Enantioselective Bismethoxycarbonylation-of-Terminal-Olefins

Ying-Xiang Gao, Le Chang, Hang Shi, Bo Liang, Kittiya Wongkhan, Duangduan Chaiyaveij, Andrei.S. Batsanov, Todd.B. Marder,* Chuang Chuang Li,* Zhen Yang,* Yong Huang* Adv, Synth. Catal. 2010352, 1955-1966.


2. Enantioselective Organo-Cascade Catalysis

Yong Huang, Abbas M. Walji , Catharine H. Larsen, and David W. C. MacMillan *, J. Am. Chem. Soc. 2005127, 15051-15053.


1. Hydrogen bonding: Single enantiomers from a chiral-alcohol catalyst

Yong Huang, Aditya K. Unni, Avinash N. Thadani and Viresh H. Rawal*, Nature 2003424, 146-146.



1. “A method to Prepare Nitriles” 201210447319.X
2. "Methods of Preparing Ketones and Their Derivatives" 201110252324.0
3. "Preparation of Cyclopropyl Compounds Containing Pyridine and Pyrimidine Rings as GPR119 Receptor Agonists for the Treatment of Type 2 Diabetes and Related Diseases" WO2009129036
4. "Preparation of Bipiperidinyl Compounds as GPR-119 Agonists for Treating and Preventing Diabetes" WO2008085316
5. "Acyl Bipiperidinyl Compounds as G-protein Coupled Receptor GPR-119 Agonists, Their Preparation, Compositions Containing Such Compounds and Methods of Treatment" WO2008076243
6. "Methods of Performing Cycloadditions, Reaction Mixtures, and Methods of
Performing Asymmetric Catalytic Reactions" US 7230125